PhenoCycler-Fusion System by Akoya Biosciences

Research | Usability | Industrial Design | Innovation | Engineering| | Manufacturing Transfer

Capable of imaging 1 million cells in 10 minutes, the PhenoCycler-Fusion System is the fastest spatial biology solution on the market.  This leading-edge system enables ultrahigh-plex spatial phenotyping of whole microscope slides at single-cell resolution, and integrates automated fluidics and iterative imaging functionality.

Manta supported the PhenoCycler’s development by providing User Research and Usability Engineering, Industrial Design, Engineering Development, and Design for Manufacturing expertise.

Usability & Design

Key user interactions with the PhenoCyclerTM-Fusion System include the loading and unloading of the microscope slides containing the biological samples and the fluidic coupling of the slides to the fluidics system.

Manta performed user research to identify the user requirements for the instrument, conceptualized usability solutions, and tested these with key stakeholders and experts to arrive at an optimized usability design for the overall system.

Our team uses a variety of dynamic methods to gain insights, including:

Contextual research, observation, and interviews

Ergonomics and human factors research

Task analysis and scenario development

Human factors and usability mock-ups

PhenoCycler-Fusion Sampling
Sample management

High-End Brand Communication

Akoya Bioscience sought to establish a high-end brand presence with the PhenoCycler-Fusion System, which would both differentiate the company from its competitors and reflect the instrument’s field-leading multiplex imaging technology.

Manta’s industrial designers achieved this goal by developing a cutting-edge aesthetic design that includes sweeping enclosure shapes, translucent covers, prominent accent lighting details, and a bold color palette.

System brainstorming and conceptualization

Industrial Design

Brand Development

Ergonomics / human factors

Sketches / illustrations

Appearance models

Akoya PhenoCycler-Fusion
High-End Brand

Engineering & Manufacturing

The PhenoCycler-Fusion System is a complex instrument that includes fluidics, robotics, and imaging technologies. The system architecture integrated multiple technologies, sub-assemblies, and was optimized for manufacturing.

Manta’s engineering design solution included a unique, multi-process internal structural frame design that simplified assembly and field service. The enclosures employed a range of manufacturing processes, including injection molding, thermoforming, and castings. Our services include:

System Architecture development

Engineering analysis

Detailed engineering design

3D CAD solid modeling and surfacing

Prototype fabrication, assembly, and testing

Design for Manufacturing and Assembly (DFMA)

PhenoCycler-Fusion Exploded View
System Architecture Exploded View

The PhenoCycler-Fusion System:

Research | Usability | Industrial Design | Engineering | Manufacturing

The result is a unique instrument form that complements the PhenoCycler-Fusion System’s high-end functional and usability performance, while standing out from competitive spatial imaging instruments.

PhenoCycler-Fusion Front View

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Drop us a line to learn more about the PhenoCycler-Fusion System.